Esperion Therapeutics, Inc. issued the following announcement on Oct. 7.
Esperion (NASDAQ: ESPR) today announced results of pooled data from two of the company’s Phase 3 trials were presented at the virtual 88th Annual Congress of the European Atherosclerosis Society (EAS 2020). Both trials demonstrated significant lowering of cholesterol by NEXLETOL® (bempedoic acid) Tablets in people with the most common form of inherited high cholesterol.1,2 The data from this pooled analysis of over 3,000 patients with Atherosclerotic Cardiovascular Disease (ASCVD) and/or Heterozygous Familial Hypercholesterolemia (HeFH) were presented by Professor P. Barton Duell, Professor of Medicine, Oregon Health & Science University and member of Esperion’s Phase 3 Steering Committee.
During the EAS presentation, it was highlighted that NEXLETOL significantly reduced low-density lipoprotein cholesterol (LDL-C) by a mean of 22% compared to placebo in people with HeFH taking maximally tolerated statins with or without other lipid-lowering therapies (LLTs). Mean LDL-C reductions from baseline to week 12 were also significantly greater with NEXLETOL vs placebo for patients without HeFH (placebo-corrected difference: –18%). Consistent with previous clinical studies, NEXLETOL was generally well tolerated in people with HeFH, with no new safety signals seen.i HeFH is a common condition affecting over 30 million people worldwide who are at increased risk of a cardiovascular event such as a heart attack.3 Additionally, it was shown that many patients with HeFH do not achieve adequate LDL-C lowering despite multidrug therapy, demonstrating a great need for efficacious non-statin LDL-C-lowering medications.
Original source can be found here.
Source: Esperion Therapeutics, Inc.
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